Reciprocal Abstracts July 2023

Abstracts - Thursday, July 22, 2004

Thursday, July 22, 2004 12 International Congress of Immunology and 4 Annual Conference of FOCIS July 18–23, 2004 • Montréal, Canada Clinical and Investigative Medicine Médecine clinique et expérimentale Vol. 27 • No. 4 • August • août • 2004 www.cma.ca/cim The 12th International Congress of Immunology and the 4th Annual Conference of FOCIS Abstracts for Thursday, July 22, 2004s for Thursday, J...

SIG Abstracts — Friday , July 10 th

List of Abstracts Monday , 5 July

An output feedback Model Predictive Control (MPC) strategy for linear systems with additive stochastic disturbances and probabilistic constraints is proposed. Given the probability distributions of the disturbance input, the measurement noise and the initial state estimation error, the distributions of future realizations of the constrained variables are predicted using the dynamics of the plan...

Dmd053322 2018..2023

In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...

Dmd059675 2023..2032

Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...